解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::This study describes the development and cell culture application of nanometer thick photocrosslinkable thermoresponsive polymer films prepared by physical adsorption. Two thermoresponsive polymers, poly(N-isopropylacrylamide (NIPAm)-co-acrylamidebenzophenone (AcBzPh)) and poly(NIPAm-co-AcBzPh-co-N-tertbutylacrylamide...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600175
更新日期:2017-02-01 00:00:00
abstract::There is an urgent unmet medical need for new treatments for wound and burn infections caused by multidrug-resistant Gram-negative "superbugs," especially the problematic Pseudomonas aeruginosa. In this work, the incorporation of colistin, a potent lipopeptide into a self-healable hydrogel (via dynamic imine bond form...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600320
更新日期:2017-02-01 00:00:00
abstract::Aggregation of denatured or unfolded proteins establishes a large energy barrier to spontaneous recovery of protein form and function following traumatic injury, tissue cryopreservation, and biopharmaceutical storage. Some tissues utilize small heat shock proteins (sHSPs) to prevent irreversible aggregation, which all...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600217
更新日期:2017-02-01 00:00:00
abstract::Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and r...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600105
更新日期:2016-11-01 00:00:00
abstract::Biopolymers are an attractive class of compounds for being used in biomedical applications as they are widely available from biomass. Their drawback is the lack of mechanical stability and the ability to tune this properly. Covalent chemical cross-linking is an often used approach but it limits usability due to legisl...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600214
更新日期:2016-11-01 00:00:00
abstract::The aim of this study is to establish the safe and effective ocular delivery system of therapeutic small interfering RNA (siRNA) in corneal neovascularization therapy. The major hurdle present in siRNA-based corneal neovascularization (CNV) therapy is severe cytotoxicity caused by repetitive drug treatment. A reducibl...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600051
更新日期:2016-11-01 00:00:00
abstract::This study aims to develop an effective method to control motile microorganisms and enable their manipulation as functional 'live micro/nano robots'. A novel strategy based on Fe3 O4 nanoparticle-doped alginate hydrogel is developed to fashion an artificial extracellular matrix (ECM) for microbial cells (e.g., Sacchar...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600143
更新日期:2016-10-01 00:00:00
abstract::Photo-crosslinking and self-healing have received considerable attention for the design of intelligent materials. A novel photostimulated, self-healing, and cytocompatible hydrogel system is reported. A coumarin methacrylate crosslinker is synthesized to modify the polyacrylamide-based hydrogels. With the [2+2] cyclo-...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500457
更新日期:2016-09-01 00:00:00
abstract::Back Cover: The authors have created polymers which release insulin using light. These materials utilize insulin itself as the primary monomer and therefore achieve a very high density (85% w/w insulin). This near perfect density makes them ideal as photoactivated depots of insulin. Further details can be found in the...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201670032
更新日期:2016-08-01 00:00:00
abstract::Traditionally, conductive materials for electrodes are based on high modulus metals or alloys. Development of bioelectrodes that mimic the mechanical properties of the soft, low modulus tissues in which they are implanted is a rapidly expanding field of research. Many polymers exist that more closely match tissue mech...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201600057
更新日期:2016-08-01 00:00:00
abstract::An increased structural variety expands the number of putative applications for cyanophycin (multi-l-arginyl-poly-[l-aspartic acid], CGP). Therefore, structural modifications of CGP are of major interest; these are commonly obtained by modification and optimization of the bacterial producing strain or by chemical modi...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500433
更新日期:2016-07-01 00:00:00
abstract::Previously synthesized amphiphilic diblock copolymers with pendant dendron moieties have been investigated for their potential use as drug carriers to improve the delivery of an anticancer drug to human breast cancer cells. Diblock copolymer (P71 D3 )-based micelles effectively encapsulate the doxorubicin (DOX) with a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500435
更新日期:2016-06-01 00:00:00
abstract::The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201500367
更新日期:2016-04-01 00:00:00
abstract::The preclinical development of nanomedicines raises several challenges and requires a comprehensive characterization. Among them is the evaluation of the biodistribution following systemic administration. In previous work, the biocompatibility and in vitro targeting ability of a glycol chitosan (GC) based nanogel have...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500267
更新日期:2016-03-01 00:00:00
abstract::Development of artificial tissues providing the proper geometrical, mechanical, and environmental cues for cells is highly coveted in the field of tissue engineering. Recently, microfabrication strategies in combination with other chemistries have been utilized to capture the architectural complexity of intricate orga...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500338
更新日期:2016-03-01 00:00:00
abstract::Cell-free approaches to in situ tissue engineering require materials that are mechanically stable and are able to control cell-adhesive behavior upon implantation. Here, the development of mechanically stable grafts with non-cell adhesive properties via a mix-and-match approach using ureido-pyrimidinone (UPy)-modified...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500278
更新日期:2016-03-01 00:00:00
abstract::Oligomerization of thiol-unprotected L-cysteine ethyl ester (Cys-OEt) catalyzed by proteinase K in aqueous solution has been used to synthesize oligo(L-cysteine) (OligoCys) with a well-defined chemical structure and relatively large degree of polymerization (DP) up to 16-17 (average 8.8). By using a high concentration...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500255
更新日期:2016-01-01 00:00:00
abstract::Vascular grafts are used to bypass damaged or diseased blood vessels. Bacterial cellulose (BC) has been studied for use as an off-the-shelf graft. Herein, we present a novel, cost-effective, method for the production of small caliber BC grafts with minimal processing or requirements. The morphology of the graft wall p...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500251
更新日期:2016-01-01 00:00:00
abstract::Molecularly imprinted polymers (MIPs) are synthetic affinity matrices capable of selective binding a specific target molecule. A strategy for competitive selectivity studies is developed providing information on the selective binding properties of MIPs in complex matrices. Batch rebinding experiments entail the target...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500106
更新日期:2015-11-01 00:00:00
abstract::This study investigates the structural features of porcine gastric mucin (PGM) in aqueous dispersions and its interactions with water-soluble polymers (poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), poly(ethylene oxide), and poly(ethylene glycol)) using isothermal titration calorimetry, turbidimetric titrati...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500158
更新日期:2015-11-01 00:00:00
abstract::The core-shell micelles in aqueous solutions were prepared at low CAC values (<0.1 mg · mL(-1) ) from amphiphilic graft copolymers consisting of poly(methyl methacrylate) backbone (120-165 units) with loosely grafted (17-40%) hydroxyl-capped PEG (9 vs 6 units in side chain) for drug loading. Hydrophobic indomethacin (...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500189
更新日期:2015-11-01 00:00:00
abstract::N-Acetyl-l-cysteine (NAC)-capped poly(methyl methacrylate)-b-polycaprolactone block copolymer (PMMA-b-PCL-NAC) was prepared using the previously described one-pot photoinduced sequential CuAAC/thiol-ene double click procedure. PMMA-b-PCL-NAC had previously shown good applicability as a matrix for cell adhesion of cell...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500099
更新日期:2015-09-01 00:00:00
abstract::Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta (Aβ) plaques in Alzheimer's disease (AD). Its timely finding would be vital for patient survival and quality of life. Curcumin (CUR), a common Indian spice effectively binds to...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500062
更新日期:2015-09-01 00:00:00
abstract::The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500060
更新日期:2015-08-01 00:00:00
abstract::Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at sub-micrometer scale. The results revealed that three-dimensional micrometer stru...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500107
更新日期:2015-08-01 00:00:00
abstract::The design and preparation of highly efficient drug delivery platforms using green methodologies is at the forefront of nanotherapeutics research. POxylated polyurea dendrimers are efficiently synthesized using a supercritical-assisted polymerization in carbon dioxide. These fluorescent, pH-responsive and water-solubl...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500131
更新日期:2015-08-01 00:00:00
abstract::In pluripotent stem cell differentiation, embryoid bodies (EBs) provide a three-dimensional [3D] multicellular precursor in lineage specification. The internal structure of EBs is not well characterized yet is predicted to be an important parameter to differentiation. Here, we use custom SU-8 molds to generate transpa...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500051
更新日期:2015-07-01 00:00:00
abstract::Intrinsic antimicrobial thermoplastic A(BC)n copolymers (n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl-aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by casting as...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400503
更新日期:2015-07-01 00:00:00
abstract::Amylose-fatty acid inclusion complexes can be easily prepared by simple mixing in hot aqueous solutions. Above a critical chain length (C6) of the fatty acid insoluble complexes between amylose and each fatty acid (C8, C10, C12, C14, C16) were precipitated from the solution, and characterized by FT-IR, XRD, DSC, and S...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400464
更新日期:2015-05-01 00:00:00
abstract::"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrostatic interaction and solvent-induced condensation of DNA. The low mole...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400488
更新日期:2015-05-01 00:00:00
abstract::Polymeric nanostructures obtained through self-assembly of reduction-sensitive amphiphilic triblock copolymers were investigated as potential drug delivery systems. The characteristic feature of these polymers is their cleavable disulfide bond in the center of the hydrophobic block. Therefore, the triblock copolymers ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400400
更新日期:2015-04-01 00:00:00
abstract::5,6-Bis(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) is a new anti cancer molecule having capability to selectively inhibit non-homologous end joining (NHEJ), one of the DNA double strand break (DSB) repair pathways inside the cells. In spite of the promising potential as an anticancer agent, hydrophobicity of SC...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400480
更新日期:2015-04-01 00:00:00
abstract::Injectable hydrogels are extensively used in drug delivery and tissue engineering to administer drugs, genes, growth factors and live cells. We report a method to produce tough, in-situ thermogelling, non-toxic, injectable hydrogels made of chitosan and hyaluronic acid co-crosslinked with β-glycerophophate and genipin...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400406
更新日期:2015-04-01 00:00:00
abstract::Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro releas...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400238
更新日期:2015-03-01 00:00:00
abstract::Gelatin nanoparticles can be stabilized by entrapping them in Eudragit E100 nanospheres. The size of the nanospheres was dependent on the homogenization speed, producing nanospheres of 433 nm (8000 rpm) and 176 nm (15000 rpm). The nanoparticle morphology was critically dependent on Eudragit E100 concentration; with 2%...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400214
更新日期:2014-11-01 00:00:00
abstract::A redox-responsive poly(ethylene glycol) (PEG)-sheddable copolymer of disulfide-linked PEG 5000-lysine-di-tocopherol succinate (P(5k)SSLV) is developed which can self-assemble into nanomicelles in aqueous condition and trigger the rapid release of encapsulated drugs within tumor cells. The reduction-insensitive doxoru...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400149
更新日期:2014-10-01 00:00:00
abstract::Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and bra...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400152
更新日期:2014-10-01 00:00:00
abstract::The synthesis of a novel nanocapsule-based carrier system is described, possessing a triggered release in remote-controlled fashion upon application of an external magnetic field in combination with the possibility to use the capsules as contrast agents for magnetic resonance imaging (MRI). Therefore, polymeric nanoco...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400122
更新日期:2014-09-01 00:00:00
abstract::Well-defined amphiphilic polymers of the ABA and ABC type are synthesized, where A is poly(L-lysine hydrochloride) (PLL), B is poly(γ-benzyl-(d7) L-glutamate) (PBLG(-d7)), and C is poly(ethylene oxide) (PEO). The two polymers exhibit similar PBLG(-d7) composition, while in the ABC, the volume fraction of PEO block is ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400137
更新日期:2014-09-01 00:00:00
abstract::A simple, robust one pot procedure for the preparation of waterborne multifunctional poly(vinyl amine)s (PVAms) is presented. By post-polymerization modification of PVAm with a bifunctional coupler and functional couplers cationic, reactive azetidinium groups, and alkyl chains are introduced in the side chains of PVAm...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300576
更新日期:2014-08-01 00:00:00